2026
Zhang L, Omarov M, Xu L, Das B, Luo H, Hauck SM, Petrera A, Yu Z, Goonewardena SN, Zeggini E, Peters A, Dichgans M, Murthy VL, Thorand B, Georgakis MK. Proteomic signatures as biomarkers of atherosclerosis burden. Cardiovasc Res. 2026 Aug 26;122(12):1589-1608. doi: 10.1093/cvr/cvag140. PMID: 42367007; PMCID: PMC13508699
Tiedt S, Vlegels N, Dimitriadis K, Li W, Jickling GC, McCullough LD, Liesz A, Lo EH, Hill MD. A roadmap towards clinical use of molecular biomarkers in acute ischaemic stroke. Nat Rev Neurol. 2026 Oct 6. doi: 10.1038/s41582-026-01270-3. Epub ahead of print. PMID: 42839011
Chen B, Prabhu A, Li G, Kaltenbach A, Wang Y, Shakir G, Natarelli L, Megens R, Jansen Y, Ramanathan S, Geiger M, Faussner A, Hristov M, Richter D, Di X, van der Stelt M, Triantafyllidou V, Li Z, Sachs N, Paloschi V, Maegdefessel L, Hofmann SM, Schifferer M, Simons M, Weber C, Santovito D, Herzig S, Guillamat Prats R, Steffens S. Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake. Nat Commun. 2026 Jul 7;17(1):5939. doi: 10.1038/s41467-026-75214-2. PMID: 42414306; PMCID: PMC13342577
Hoermann L, Seker FB, Joseph E, Kirchleitner SV, Blobner J, Kunze LH, Thevis JF, Hummel S, Englert AL, Wind-Mark K, Holzgreve A, Lindner S, Werner RA, von Baumgarten L, Albert NL, Plesnila N, Brendel M, Bartos LM. Allocation of TSPO-PET signals to cellular and extracellular compartments in dependence of blood-brain barrier disruption in experimental glioblastoma. Eur J Nucl Med Mol Imaging. 2026 Sep 24. doi: 10.1007/s00259-026-08187-5. Epub ahead of print. PMID: 42778718
Delgado Jiménez R, Ruggles A, Adedokun MA, Sorbie A, Fink D, Laudani S, Simats A, He Y, Pahl V, Díaz-Marugán L, Voss M, Singh K, Lledós M, Carofiglio O, Melton P, Pinkham K, Ricci A, Roth S, Sadler R, Khayat S, Mousavi SM, Tsaktanis T, Tobinski AM, Walter C, Ohnmacht C, Huehn J, Herkel J, Carambia A, Klotz L, Gelderblom M, Rothhammer V, Regen T, Bernhagen J, Gigl M, Zimmermann M, Fernandez-Cadenas I, Hirt L, Delacher M, Liesz A, Benakis C. Gut microbiota primes stroke severity via the AHR in intestinal dendritic cells. Cell. 2026 Sep 29:S0092-8674(26)01115-3. doi: 10.1016/j.cell.2026.09.013. Epub ahead of print. PMID: 42810339.
Klimmt J, Cardoso Gonçalves C, Montgomery JV, Müller SA, Bublitz M, Filser S, Paeger L, Nuscher B, Dannert A, Roeber S, Pravata V, Schifferer M, Shrouder JJ, Schulz N, González-Gallego J, Cappello S, Misgeld T, Plesnila N, Beltrán E, Herms J, De Domenico E, Beyer MD, Schultze JL, Haass C, Lichtenthaler SF, Carraro C, Paquet D. A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes. Nat Neurosci. 2026 Aug 4. doi: 10.1038/s41593-026-02367-0. Epub ahead of print. PMID: 42552384.
Mahabhashyam S, Harris J, Bernhagen J, Vinh A, Mirabito Colafella KM. The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease. Br J Pharmacol. 2026 Jul 17. doi: 10.1111/bph.70584. Epub ahead of print. PMID: 42468973.
Noterman-Soulinthavong MF, Sancho M, de la Cruz SH, Yarboro M, Mandalà M, Koide M, Beaufort N, Todorov-Völgyi K, Moreland E, Hill-Eubanks D, Dichgans M, Nelson MT. Endothelial Arf6 sustains electrical signaling and cerebral blood flow in mice through PIP2-dependent activation of Kir2.1 channels. Proc Natl Acad Sci U S A. 2026 Jul 14;123(28):e2615120123. doi: 10.1073/pnas.2615120123. Epub 2026 Jul 7. PMID: 42412927.
Chen B, Prabhu A, Li G, Kaltenbach A, Wang Y, Shakir G, Natarelli L, Megens R, Jansen Y, Ramanathan S, Geiger M, Faussner A, Hristov M, Richter D, Di X, van der Stelt M, Triantafyllidou V, Li Z, Sachs N, Paloschi V, Maegdefessel L, Hofmann SM, Schifferer M, Simons M, Weber C, Santovito D, Herzig S, Guillamat Prats R, Steffens S. Endothelial cannabinoid CB1 receptor deficiency reduces shear stress-induced arterial inflammation and lipid uptake. Nat Commun. 2026 Jul 7;17(1):5939. doi: 10.1038/s41467-026-75214-2. PMID: 42414306; PMCID: PMC13342577.
Wiesbeck M, Alard EL, Merino F, Chowdhury N, Egert L, Danese A, Imhof S, Iraci Borgia M, Rajan A, Fernandez-Novel Marx N, Kepesidis E, Köferle A, Cerron-Alvan LM, Vierl F, Truong TT, Thorwirth M, Bilalli L, Ninkovic J, Schieweck R, Diefenbacher M, Hauck SM, Trainor P, Mardakheh FK, Götz M, Stricker SH. Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription. Science. 2026 Jul 2:eaeh1348. doi: 10.1126/science.aeh1348. Epub ahead of print. PMID: 42391322.
Zangas P, Schuermans A, Georgakis MK. Genetically Proxied Interleukin-6 Signaling Inhibition and Heart Failure Risk. JACC Heart Fail. 2026 Apr 7:103057. doi: 10.1016/j.jchf.2026.103057. Epub ahead of print. PMID: 41954542.
Chayama Y, Rao NR, Perla D, Zhang Z, Reid M, Nelson S, Wen X, Ding B, Blumenfeld J, Apolonio A, Doddipalli S, Zhou H, Turhan SG, Shih PY, Brendel M, Fu YH, Ertürk A, Kolabas ZI, Huang Y, Yang AC. Physiological brain clearance architecture revealed by neuronal protein tracing. Cell. 2026 May 29:S0092-8674(26)00515-5. doi: 10.1016/j.cell.2026.04.048. Epub ahead of print. PMID: 42214342; PMCID: PMC13225612.
Kaltenecker D, Horvath I, Al-Maskari R, Chen Y, Kolabas ZI, Hoeher L, Todorov M, Minde DP, Kapoor S, Turhan SG, Kuemmerle LB, Steinke H, Wohlgemuth T, Ali M, Kofler F, Morigny P, Geppert J, Jeridi D, Wittmann B, Luo J, Shit S, Cigankova C, Kolenic VM, Gür N, Aydeniz E, Yücecan A, Ertürk M, Simons LHA, Pan C, Piraud M, Rueckert D, Rohm M, Hellal F, Elsner M, Bhatia HS, Bechmann I, Menze BH, Herzig S, Paetzold JC, Diaz MB, Ertürk A. A deep-learning framework reveals whole-body perturbations at cell level. Nature. 2026 May 20. doi: 10.1038/s41586-026-10535-2. Epub ahead of print. PMID: 42162424.
Zangas P, Georgakis MK. Genetic Variation in the Chemokine Network and Atherosclerosis Risk. Curr Atheroscler Rep. 2026 Mar 13;28(1):31. doi: 10.1007/s11883-026-01401-7. PMID: 41824188; PMCID: PMC12987826.
Llovera G, Heindl S, Varga DP, Lenart N, Kallabis S, Göb V, Stegner D, Escaig R, Nicolai L, Franzmeier N, Meissner F, Denes A, Liesz A. Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA. EMBO Mol Med. 2026 Mar 20. doi: 10.1038/s44321-026-00397-6. Epub ahead of print. PMID: 41862768.
